Metformin, a type 2 diabetes drug, may help the immune system to better identify cancer cells and boost the immune response against them, according to a study conducted at the University of Helsinki, said the university in a press release on Friday.
Metformin is a widely prescribed drug for managing type 2 diabetes. In recent years, indications of its potential anticancer properties have emerged in research.
The newly published study found that metformin activates the body’s immune cells. The effect was particularly observed in what are known as dendritic cells, which are the most effective in helping the immune system identify cancer cells as foreign entities.
“Our study found that metformin contributed to the metabolism of dendritic cells so that they became active and enhanced the immune response against cancer cells,” said Rita Turpin, the first author of the study.
Identifying this effect can help to develop anticancer therapies based on the combined effect of metformin and the mechanisms that activate the immune system.
The researchers investigated the effects of metformin in human breast cancer tissue samples, which contained living cancer cells and immune cells that had infiltrated the cancer tissue.
The living tissue cultures used in the study, known as patient-derived explant cultures, show what cancer drugs do to cancer cells and, at the same time, what they do to immune cells that have penetrated the cancer tissue.
Research group leader Juha Klefström considers the study groundbreaking.
“Our work demonstrates that we can learn a lot about how cancer drugs influence tumour-resident immune cells by investigating living patient-derived tumour samples” he said.
According to Klefström, patient-derived explant cultures can be used to identify drugs that kill cancer cells but leave the immune cells unharmed. Or they can be used to find safe and tolerable drugs, such as metformin, which help immune cells to become active and defend against cancer.
Without breast cancer patients donating tumour samples, such research would not be possible.
“We are truly grateful to all the patients who participated in the study for their invaluable contribution to the promotion of cancer research,” Klefström said.
Source: www.dailyfinland.fi
I find the study fascinating! It’s amazing how a diabetes drug like metformin could potentially boost the immune system against cancer cells. This could be a promising development in the fight against breast cancer.
Does metformin have similar effects on other types of cancer cells besides breast cancer?
Yes, Emily80, studies have shown that metformin may also have positive effects on other types of cancer cells, such as colon, prostate, and pancreatic cancer. Research suggests that metformin’s ability to enhance the immune response against cancer cells is not limited to breast cancer. It’s an exciting area of ongoing research with promising results.
As a regular user of metformin for my type 2 diabetes, I am pleasantly surprised by this study’s findings. It’s reassuring to know that the medication not only helps manage my diabetes but also potentially boosts my body’s ability to fight cancer. This research opens up exciting possibilities for future anticancer therapies. Kudos to the researchers for this valuable contribution!
As someone who has type 2 diabetes, I find this study fascinating. If metformin can also help fight cancer, it would be a game-changer in managing both conditions effectively.
Could metformin potentially be used as a complementary treatment for cancer alongside conventional therapies?
As a medical researcher myself, I find this study incredibly promising. Metformin’s ability to activate immune cells and enhance the immune response against cancer cells could revolutionize cancer treatment methods. Looking forward to more advancements in this field!
Could metformin potentially be used as a primary treatment for cancer patients in the future?